Evaluatieagenda
Met welke zorgevaluaties onderzoeken we op dit moment de effectiviteit van de zorg?
Evaluatieagenda per specialisme
- Anesthesiologie
- Apotheek
- Cardiologie
- Dermatologie
- Diëtetiek
- Eerstelijn
- Endocrinologie
- Fysiotherapie
- Geriatrie
- GGZ
- Gynaecologie
- Heelkunde
- Hematologie
- Huisarts
- Immunologie
- Intensive Care
- Interne Geneeskunde
- Kindergeneeskunde
- Klinische chemie
- KNO
- Longgeneeskunde
- MDL
- Medische Microbiologie
- Medische Psychologie
- Nefrologie
- Neurochirurgie
- Neurologie
- Oncologie
- Oogheelkunde
- Orthopedie
- Plastische Chirurgie
- Psychiatrie
- Radiologie
- Reumatologie
- Revalidatiegeneeskunde
- SEH
- Thoraxchirurgie
- Traumatologie
- Urologie
- Verpleegkunde
- Ziekenhuisbreed
Wat we doen
Onderwerpen
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Low dose cisplatin weekly versus high dose cisplatin every three weeks with radiotherapy in sarcopenic head and neck cancer patients
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Short course aminoglycosides as adjunctive treatment in adults with sepsis
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Pharmacokinetic boosting of olaparib to improve exposure, tolerance and cost-effectiveness (PROACTIVE)
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Comparing antidepressant (AD) tapering strategies for paroxetine and venlafaxine: the TAPER-AD trial
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Optimal postoperative pain management after video-assisted thoracoscopic lung resection
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Patient guided dose reduction strategy of Tyrosine Kinase Inhibitors in chronic myeloid leukemia: rodeo study
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Transmural collaborative care model for cardiovascular risk management and medication review for patients using antipsychotics (TACTIC): feasibility and evaluation study
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SIck Day Rule Implementation to prevent acute Kidney injury in community-dwelling patients (SIDRIK-study)
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Optimising medication with focus on deprescribing in frail older people with multidose drug dispensing systems
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DISTANCE
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Multi-institutional Evaluation of the Cost-effectiveness of PSMA-PET/CT for the Detection of Pelvic Lymph Node Invasion in Newly Diagnosed Prostate Cancer Patients (PSMA-SELECT)
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GO TEST
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CURVE
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EXPRESS
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FLOW
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GENPAD
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Gebruik van Procalcitonine-bepaling om therapiefalen te verminderen bij COPD exacerbaties
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INSIGHT
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Improve diagnostic pathway in acute onset, continuous dizziness
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NABOR
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LIMONCELLO
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PREPARATION
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GOAL
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RECOVER
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CLEAR-CAD
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SAFEST
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UPDATE
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ICD: meerwaarde voor patiënten met bindweefsel in het hart?
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CHildren with Arthritis: Monotherapy or Polytherapy (CHAMP). A multicentre, single-blinded, randomized treat to target, one-year follow-up clinical trial in patients with recent onset juvenile idiopathic arthritis (JIA)
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PROTECT: Personalized treatment of immunosuppressive and antifungal drugs through continuous home based monitoring with Dried Blood Spot sampling techniques in pediatric patients.
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Tailored intervention focused on self-management and acceptance to improve adherence of patients with haemophilia using prophylactic home treatment.
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Optimalization of Eculizumab/Soliris® treatment in patients with atypical hemolytic uremic syndrome by means of individually-tailored, personalized therapy.
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EFFICACY OF OPTIMIZED THIOPURINE THERAPY IN ULCERATIVE COLITIS
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Introduction of a biomarker-guided treatment-and-stop-strategy for recombinant IL-1receptor antagonist (anakinra) in patients with systemic Juvenile Idiopathic Arthritis
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TailoRing anti-androgEn therapy For metastatic castration resistant prostate cancer based on early tumor response markers In combiNation with drug Exposure measurement (REFINE-project)
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Insulin regime versus oral therapy for Diabetes in pregnancy: the SUGAR-DIP trial
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Analgosedation after cardiac surgery in infants: A 'model-based' nation-wide randomized controlled trial.
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Autologe Vettransplantatie (AFT) bij borstreconstructies na borstkanker; de techniek van de toekomst bij borstreconstructies.
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Assessing the cost-effectiveness of withdrawing growth hormone treatment after mid-puberty in adolescents with idiopathic isolated growth hormone deficiency
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DART - The cost-effectiveness of surgery versus casting for elderly patients with intra-articular distal radius fractures.
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The Dutch Injection versus Surgery TRIal in CTS patients (DISTRICTS): a multi-center randomized controlled trial comparing two treatment strategies
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The CoSy-trial: Internet-based sex Counseling and chances on natural conception in couples with idiopathic Subfertility: a randomized clinical trial
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Behavioural activation delivered by mental health nurses versus treatment as usual for late-life depression in primary care
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Delirium in Elderly Patients with Trauma of the Hip - DEPTH-Project
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Walk and Talk; A Randomized Controlled Trial of High Intensive Treatment versus Care as Usual for Posttraumatic Stress Disorder.
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Early initiation of extracorporeal life support in refractory ventricular fibrillation
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Rapid Access to Contrast-Enhanced spectral mammogRaphy (RACER): a more efficient work-up of women recalled from breast cancer screening
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Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault >30%)?
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BeNeDuctus Trial
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Equally good, with less: Omitting the sentinel node biopsy in clinically node negative early breast cancer patients
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A Randomized Controlled Trial on Prophylactic Platelet Transfusion Prior to Central Venous Catheter Placement in Patients with Thrombocytopenia - PACER TRIAL -
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Initial non-operative treatment strategy versus appendectomy treatment strategy for simple appendicitis in children aged 7- 17 years old. APAC study
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Economic evaluation of psychiatric rehabilitation/self-management group intervention (PPEP4All) compared with usual care in patients with Persistent Depressive Disorder (PDD) and their partner; a multicenter pragmatic randomized controlled trial
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Non-invasive diagnosis and treatment of neonatal jaundice in primary care
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Home-based monitoring of ovulation to time frozen embryo transfer in IVF (natural FET study)
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Clinical impact of dedicated MR staging of ovarian cancer patients
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Corticosteroids for treatment of chronic subdural hematoma (ChERISH)
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Dutch TRUFFLE: the UmbilicoCerebral Ratio in late preterm Fetal Growth Restriction
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Supplemental oxygen strategies in children with bronchopulmonary dysplasia (BPD) after the neonatal intensive care period: the SOS BPD study.
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Effectiviteit van antibacteriële verbandmiddelen bij constitutioneel eczeem
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GERiatric Screening in the treatment of elderly patients with Ovarian Carcinoma (GERSOC)
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MR Proper: Risk assessment and MR imaging in prostate cancer diagnosis: an impact analysis
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Proclion - Prospective evaluation of interventions for critical limb ischemia
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The (cost)effectiveness of neoadjuvant FOLFIRINOX versus upfront surgery for (borderline) resectable pancreatic cancer.
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Cost-effectiveness of immediately versus delayed sequential bilateral cataract surgery (ISBCS vs. DSBCS)
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Surgical Approach of Hemiarthroplasty after Femoral Neck Fracture: Posterolateral or Direct Lateral (APOLLO)
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Effectiveness of Continuous Glucose Monitoring versus stepped Care starting with HypoAware, A Web-Based Psychoeducational Intervention, and adding CGM as needed, in Adult Type 1 Diabetes and Impaired Hypoglycemia Awareness: A Randomized Controlled Trial
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Improvement of quality of life with home dialysis compared to in-centre haemodialysis? The DOMESTICO project
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Cost-effectiveness of specialized nursing interventions for patients with Parkinson’s disease
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EFFectiveness of total Extraperitoneal hernia Correction for clinically occulT inguinal hernia (EFFECT trial): a multicenter randomized controlled trial
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Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in The Netherlands for Late arrivals: MR CLEAN-LATE
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Klinische en kosteneffectiviteit van gerichte nazorg voor patiënten met mogelijke cognitieve en emotionele klachten na een TIA of kleine beroerte, die rechtstreeks uit het ziekenhuis naar huis ontslagen kunnen worden
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New AntiBiotic treatment Options for uncomplicated GOnorrhoea (NABOGO trial) - a double-blind randomized controlled non-inferiority trial
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Lengthening Adalimumab Dosing Interval in quiescent Crohn’s disease patients: the LADI study.
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Optimising anticoagulant management in frail elderly patients with AF: the FRAIL-AF study.
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Intravenous-to-oral antibiotic switch therapy for suspected neonatal infections: clinical efficacy, safety and cost-effectiveness.
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Topical or oral antibiotics for children with acute otitis media presenting with ear discharge?
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Non-inferiority multicentre randomized controlled trial comparing a short versus a long course of postoperative antibiotic treatment for complex acute appendicitis
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CARRIER-trial: Long-term StaphyloCoccus aureus decolonizAtion in patients on home parenteRal nutRition: a randomIzed multicEnter tRial.
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Efficacy and cost analysis of oral alitretinoin versus oral cyclosporine in patients with severe chronic vesicular hand eczema. A randomized controlled prospective open-label trial with blinded outcome assessment.
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Efficacy and safety of off label low dose antidepressants (amitriptyline and mirtazapine) for chronic insomnia: a double-blind, randomized placebo-controlled trial in general practice
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Optimizing osteoporosis treatment outcomes: shared-decision making and adherence support program
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Pharmacogenetics to improve personalized antidepressant dosing in patients with severe depression;a randomized controlled trial using Tricyclic Antidepressants
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Tailored treatment of functional dyspepsia with nortriptyline: a multi-center double-blind placebo-controlled trial (TENDER)
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Chronotherapy with aspirin for reduction of cardiovascular disease (TImE ASPIRIN)
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Withdrawing off-label antipsychotics in people with intellectual disabilities: why does it fail?
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Individualized PeMetRexed dOsing in lung cancER and mesothelioma patients to improVE treatment response and allow treatment of patients with impaired renal function – The IMPROVE study (previous acronym: PROPER study).
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Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP (OPTIC trial)
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Adjuvant VACcination against HPV in surgical treatment of ClN-lesions, a Randomized Controlled Trial (VACCIN study)'
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Pharmacokinetic boosting of osimertinib in patients with non-small cell lung cancer using cobicistat
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Prudent medication management in the last phase of life
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Effectiveness of Somatostatin Analogues in Patients with hereditary hemorrhagic telangiectasia and symptomatic gastrointestinal bleeding, the SAIPAN-trial: a multicenter, randomized, open-label, parallel-group, superiority trial.
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Leiden Thrombosis Risk Prevention: Tailored treatment after a first venous thromboembolism (L-TRiP study)
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Dose lndividualizAtion of Beta-lactam AntiBiotics in ICU patients: to TDM or not to TDM and the effects on patient outcome'
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Pregnancy Outcomes: Effects of Metformin (POEM) study: a long term randomized controlled trial
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Posaconazole prophylaxis to prevent influenza-associated aspergillosis in critically ill patients: a randomized trial.
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DA VINCY trial: optimal Duration of Aprepitant therapy for nausea and Vomiting INduced by ChEmotherapY in children: a double-blind placebo-controlled crossover randomized phase III trial
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Autologous hematopoietic stem cell transplantation versus conventional immunosuppressive medication in early diffuse cutaneous systemic sclerosis: an international multicenter, open-label, randomized controlled trial
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The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anesthesia (PRETREAT): an adaptive, multicenter randomized controlled trial
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Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteremia (SAFE-trial)
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Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: to withdraw or to continue?
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Personalized dose reduction of biological drugs in Rheumatoid Arthritis patients using dynamic prediction
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EXtended use of FOsfomycin for the treatment of CYstitis in primary care (EXFOCY)
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Wound Infections Following Implant Removal (WIFI-2)
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Reduced Anticoagulation Targets in Extracorporeal life support (RATE)'
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Less is more: deprescribing of glucose lowering drugs in older people with Type 2 Diabetes mellitus
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Optimalisatie van de zorg voor verpleeghuisbewoners met pijn (heraanvraag 80-84800-98-22019)
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OPERA Netherlands study of Optimal, PERsonalized Antidepressant use
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Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: a prospective randomised multi-center double-blind placebo-controlled clinical trial
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To continue or not to continue... a randomized controlled trial of maintenance treatment versus discontinuation of antipsychotic medication following remission of a first psychosis.
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Atosiban versus placebo in the treatment of late threatened preterm labor (APOSTEL VIII study)
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OPTIMIZE trail: OPen label multicentre randomized Trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetilwith a low exposure tacrolimus regimen ln combination with everolimus in de novo renal transplantation in Elderly patients'.
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The safety and cost-effectiveness of discontinuing disease modifying therapies in stable relapsing-remitting multiple sclerosis (DOT-MS) : a randomized rater-blinded multicenter trial
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LT4/LT3 Combination therapy for hypothyroidism (T3-4-Hypo trial)
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ACTION-1: ACT guided heparinization during open abdominal aortic aneurysm repair, a randomised trial
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DUTCH-AF Registry - Prospective evaluation of dosing and adherence of anticoagulant treatment and the risk for bleeding in atrial fibrillation (NOAC)
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SONIA - Endocrine therapy plus CDK 4/6 inhibition in first or second line for hormone receptor positive advanced breast cancer
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Control Crohn Safe with episodic adalimumab monotherapy as first line treatment trial (Futurelab)
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Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands (DECISION)
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Transmural Trauma Care Model
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Multicentre randomized clinical trial in resuscitation of preterm infants at birth with intact umbilical cord: The Aeration, Breathing and then Clamping (ABC) Study
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Hernia Exploration oR Not In Infants Analysis (HERNIIA-trial): A randomized controlled trial to study the effectiveness and cost-effectiveness of contralateral surgical exploration during unilateral inguinal hernia repair in children.
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Improving the quality of life of patients with breast cancer-related lymphedema by lymphaticovenous anastomosis (LVA): A randomized controlled trial.
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Cognitive control training (CCT) as an add-on intervention in elderly depressed patients
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Cost-effectiveness of lower extremity nerve decompression surgery in diabetic subjects.
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Primary care decision rule for chest pain using the marburg heart score rule and point of care tests (POB HELP)
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Is InnFocus Microshunt (IMS) implantation a cost-effective alternative to standard trabeculectomy (TE)?
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Evaluating the utility of bone grafts in open wedge corrective osteotomy and plate fixation in patients with malunited distal radius fractures (WOPPeR trial)
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Cost-effectiveness of early fixation versus conservative therapy of multiple, simple rib fractures (FixCon); a multicenter Randomized Controlled Trial
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The Driving prEsSure durIng GeNeral AnesThesIa for abdOmiNal surgery (DESIGNATION) trial
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Face-to-face vs Online Hypnotherapy for the treatment of Irritable Bowel Syndrome (FORTITUDE)
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Cost-effectiveness of rTMS/CBT as next step in antidepressant non-responders. A randomized comparison with current stepped care approaches to major depressive disorder
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The TRIASSIC study: Multicentre, randomised controlled trial comparing TRansanal minimal InvAsive Surgery (TAMIS) and endoscopic Submucosal dIsseCtion (ESD) for resection of non-pedunculated rectal lesions.
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Induction of labour in hospital with a Foley catheter or oral misoprostol versus induction of labour at home with Foley catheter or oral misoprostol (PROBAAT-III): a multicentre randomized controlled trial with cost-effectiveness analysis.
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(Cost)-effectiveness of optical coherence tomography versus regular punch biopsy in the diagnosis and subtyping of basal cell carcinoma: a multi-center randomized non-inferiority trial
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Cost-effectiveness of a transmural integrated care program for knee arthroplasty patients in the working population
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Optimising management of children with chronic gastrointestinal symptoms: a randomised controlled trial evaluating the effect of faecal calprotectin on the referral rate in primary care.
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Surgical or Medical treatment of Endometrioma (SOMA trial)
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Acute rule out of non-ST segment elevation acute coronary syndrome in the (pre)hospital setting by HEART score assessment and a single point of care troponin. The ARTICA randomized trial
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The THumb osteoarthritis Exercise TriAl (THETA); a multicenter, randomized controlled trial on exercise therapy with an orthosis compared to an orthosis alone in patients with thumb base osteoarthritis
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The (cost-)effectiveness of patient-tailored interdisciplinary Medical Specialist Cancer Rehabilitation compared with usual care in patients with complex adverse effects of cancer or the treatment
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Dedicated MR imaging vs surgical staging of peritoneal carcinomatosis in colorectal cancer patients; a randomised multicenter trial.
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Paravertebral catheter versus Epidural analgesia in Minimally Invasive Esophageal Resection: a randomized controlled multicenter trial (PEPMEN trial)
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The Effect of Appendectomy in Ulcerative Colitis patients with active disease: COlonic Salvage by Therapeutic Appendectomy (COSTA study)
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How should we treat a patient with a distal radius fracture after closed reduction? A cluster RCT
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Adjunctive physical exercise to improve psychological and pharmacological treatment outcomes in major depressive disorder: cost-effectiveness analysis alongside a randomised comparison of usual care versus enhanced care
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Cost-effectiveness and effectiveness of rubber band ligation versus sutured mucopexy versus haemorrhoidectomy in patients with recurrent haemorrhoidal disease: a multicentre, randomized controlled trial
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Outcome and cost-effectiveness of a dynamic Lucerne-cast versus immobilization by forearm-cast in patients with FraCtures (neck, sHaft, intra-Articular) of the MetacarPAl bone, requirinG Non-operative trEatment. SHORT-TITLE: CHAMPAGNE-study
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Effectiveness and cost-effectiveness of internet-based treatment of insomnia in depressed patients treated at a mental healthcare institution
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The value of a decision aid for shared decision making in surgical and orthopedic practice. A multicenter costeffectiviness analysis.
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The SIX (Shoulder Injection and eXercise) Study; A pragmatic study for the treatment of persistent shoulder pain in primary care
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GOLD study: Glioblastoma, Optimizing Logistics and Dose.
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Time-limited versus open-ended treatment for anorexia nervosa: a health-economic evaluation alongside two paired prospective cohorts
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CRyoballoon Ablation versus mediCal thErapy in patients with Heart Failure and atrial fibrillation: a multicenter randomized clinical trial, the RACE-8-HF trial
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The effects of Automated Closed-loop versus convenTIonal VEntilation on duration and quality of ventilation (‘ACTIVE’) - a randomized clinical trial in intensive care unit patients
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Which patient with an anterior cruciate ligament rupture will need a surgical reconstruction?
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Retaining or removing the joint in the foot? A randomized controlled multicenter trial of primary arthrodesis versus joint stabilisation in Lisfranc fracture dislocation midfoot injuries.
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The Cerebro Placental Ratio as indicator for delivery in perception of reduced fetal movements (CEPRA-study).
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Hypnotherapy through self-exercises in children with functional abdominal pain in primary care
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Bronchodilators for wheeze in young children presenting to primary care: a randomised, placebo-controlled, multicentre, parallel group trial
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6-week mortality in patients treated with azole-echinocandin duo-therapy versus azole monotherapy. A randomized pragmatic superiority trial (DUET study)
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Dose reduction of the new generation biologics (1L17 and lL23 inhibitors) in psoriasis: A pragmatic, multicentre, randomized, controlled, non-inferiority study - BeNeBio study
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Survival and Quality of Life after Early Surgical Intervention versus Wait-and-See in Elderly patients with a Traumatic Acute Subdural Hematoma: a pragmatic randomized controlled trial with multicentre parallel group design (RESET ASDH study).
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The impact of high versus standard enteral protein provision on functional recovery following Intensive Care admission: a randomized controlled, multicenter, parallel group trial in mechanically ventilated, critically ill patients
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CAPP Behandeling van complexe appendicitis bij kinderen; directe appendectomie of initieel non-operatieve behandeling?
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CLEOPATRA Cost and health Effectiveness of CT Perfusion for Patients with Acute Ischemic Stroke
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DIALOGICA Samen op weg naar betere besluitvorming over wel of geen dialyse bij de oudere patiënt. (DIALOG: DIALysis or not: Outcomes in older kidney patients with Geriatric assessment)
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HollAND Comparison of rubber band ligation and haemorrhoidectomy in patients with symptomatic haemorrhoids, a multicentre, randomized controlled trial and cost-utility analysis.
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MIRA 2 A randomised controlled trial comparing Endometrial abLation alone versus Endometrial Ablation and levoNORgesterol releasing intrauterine system combined
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OASIS De optimale chirurgische strategie voor het creëren van een vaattoegang bij oudere dialysepatiënten
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PERISCOPE Perfusie MRI van primaire en secundaire hersentumoren
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PINOT Optimale behandelingstrategie voor meest voorkomende handfracturen en -luxaties
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PaTIO PhysiotherApeutic Treat-to-target Intervention after Orthopaedic surgery
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PreCOLO Prehabilitatie van oudere patiënten voorafgaand aan OK voor verwijdering colorectaalcarcinoom: praktijkvariatie reductie en kosteneffectiviteit
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STONE Effectiviteit van nefrostomiecatheter versus double J catheter bij patienten met obstructief niersteenlijden
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DM - Gerandomiseerd onderzoek naar effecTieve behANdelinG vOlgens nieuwe criteria zwangerschaps Diabetes Mellitus
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ToF Live birth rate after cleavage-stage versus blastocyst stage embryo transfer in good prognosis IVF/ICSI cycles