Specialismen

Low dose cisplatin weekly versus high dose cisplatin every three weeks with radiotherapy in sarcopenic head and neck cancer patients

Low dose cisplatin weekly versus high dose cisplatin every three weeks with radiotherapy in sarcopenic head and neck cancer patients

Short course aminoglycosides as adjunctive treatment in adults with sepsis

Pharmacokinetic boosting of olaparib to improve exposure, tolerance and cost-effectiveness (PROACTIVE)

Comparing antidepressant (AD) tapering strategies for paroxetine and venlafaxine: the TAPER-AD trial

Optimal postoperative pain management after video-assisted thoracoscopic lung resection

Patient guided dose reduction strategy of Tyrosine Kinase Inhibitors in chronic myeloid leukemia: rodeo study

Transmural collaborative care model for cardiovascular risk management and medication review for patients using antipsychotics (TACTIC): feasibility and evaluation study

Transmural collaborative care model for cardiovascular risk management and medication review for patients using antipsychotics (TACTIC): feasibility and evaluation study

SIck Day Rule Implementation to prevent acute Kidney injury in community-dwelling patients (SIDRIK-study)

SIck Day Rule Implementation to prevent acute Kidney injury in community-dwelling patients (SIDRIK-study)

Optimising medication with focus on deprescribing in frail older people with multidose drug dispensing systems

Optimising medication with focus on deprescribing in frail older people with multidose drug dispensing systems

DISTANCE

DISTANCE: Onderzoek naar controle na een operatie voor stadium II/III darmkanker (follow-up).

PSMA-SELECT

PSMA-SELECT: onderzoek naar minder lymfklieroperaties bij patiënten met prostaatkanker (diagnostiek).

GO TEST

GO TEST: Jicht: Urinezuur verlagende behandeling, behandel-naar-doel (BND) of behandel-naar-symptoom (BNS) aanpak?

CURVE

CURVE: scoliose; (kosten-)effectiviteit van minder röntgencontrole bij kinderen (follow-up/nazorg).

EXPRESS

EXPRESS: Polyneuropathie - onderzoek naar de kosteneffectiviteit van bloedtests bij de diagnose.

FLOW

FLOW: hemodialyse - kan de huidige nazorg van de vaattoegang veilig achterwege gelaten worden?

GENPAD

GENPAD: perifeer arterieel vaatlijden (PAV) - DNA onderzoek-geleide strategie bij het voorschrijven van bloedverdunners als standaard behandeling, of clopidogrel?

PRECISION

PRECISION: COPD exacerbaties - Procalcitonine-bepaling om therapiefalen te verminderen.

INSIGHT

INSIGHT: gestructureerde nazorg voor lymfeklierkanker overlevenden.

PROVIDE

PROVIDE: Onderzoek naar optimale diagnostiek van patiënten met acuut ontstane, continue duizeligheid zonder neurologische uitval op spoedeisende hulp.

NABOR

NABOR: Niet-uitgezaaide borstkanker: personaliseren van nacontrole- en nazorgplan.

LIMONCELLO

LIMONCELLO: oudere mensen met polyfarmacie - medicatiegerelateerde heropnames voorkomen met integrale medicatiezorg?

PREPARATION

PREPARATION: Kwetsbare patiënten voor wie een operatie gepland wordt; preoperatief multidisciplinair overleg voor betere behandelbeslissingen.

GOAL

GOAL: Opgenomen oudere patiënten met cognitieproblemen: proactieve zorgplanning voor beter passende zorg?

RECOVER

RECOVER: prostaatkanker - operatie, of bestraling met hormoontherapie?

CLEAR-CAD

CLEAR-CAD: Pijn op de borst; diagnostiek om vernauwing van de kransslagaders te beoordelen. Eerst een CT-scan maken?

SAFEST

SAFEST: oudere patiënten die recent een herseninfarct of TIA hebben gehad - wel of niet behandelen met cholesterolverlagende medicijnen (statines)?

UPDATE

UPDATE: volwassenen met atopisch eczeem - helpt lichttherapie?

HAKA

HAKA: heup- of knieprothese; zijn controles na 1 en 10 jaar wel nuttig?

DIDAC

DIDaC: Longkanker: kan immunotherapie bij bepaalde patiënten korter gegeven worden?

2-DECIDE

2-DECIDE: effectiviteit van beslisondersteuning voor cardiovasculair risicomanagement bij mensen met hart- en vaatziekten.

REPLACE

REPLACE: Het effect van katheter vervanging bij patiënten met katheter geassocieerde urineweginfectie.

DUTCH-ICD: meerwaarde voor patiënten met bindweefsel in het hart?

Wat is de meerwaarde van behandeling met een implanteerbare cardioverter-defibrillator (ICD) therapie voor primaire preventie bij patiënten met non-ischemische cardiomyopathie (NICM)?

CHildren with Arthritis: Monotherapy or Polytherapy (CHAMP). A multicentre, single-blinded, randomized treat to target, one-year follow-up clinical trial in patients with recent onset juvenile idiopathic arthritis (JIA)

PROTECT: Personalized treatment of immunosuppressive and antifungal drugs through continuous home based monitoring with Dried Blood Spot sampling techniques in pediatric patients.

Tailored intervention focused on self-management and acceptance to improve adherence of patients with haemophilia using prophylactic home treatment.

Tailored intervention focused on self-management and acceptance to improve adherence of patients with haemophilia using prophylactic home treatment

Optimalization of Eculizumab/Soliris® treatment in patients with atypical hemolytic uremic syndrome by means of individually-tailored, personalized therapy.

EFFICACY OF OPTIMIZED THIOPURINE THERAPY IN ULCERATIVE COLITIS

Introduction of a biomarker-guided treatment-and-stop-strategy for recombinant IL-1receptor antagonist (anakinra) in patients with systemic Juvenile Idiopathic Arthritis

TailoRing anti-androgEn therapy For metastatic castration resistant prostate cancer based on early tumor response markers In combiNation with drug Exposure measurement (REFINE-project)

Insulin regime versus oral therapy for Diabetes in pregnancy: the SUGAR-DIP trial

Analgosedation after cardiac surgery in infants: A 'model-based' nation-wide randomized controlled trial.

Assessing the cost-effectiveness of withdrawing growth hormone treatment after mid-puberty in adolescents with idiopathic isolated growth hormone deficiency

DART - The cost-effectiveness of surgery versus casting for elderly patients with intra-articular distal radius fractures.

The Dutch Injection versus Surgery TRIal in CTS patients (DISTRICTS): a multi-center randomized controlled trial comparing two treatment strategies

Delirium in Elderly Patients with Trauma of the Hip - DEPTH-Project

Early initiation of extracorporeal life support in refractory ventricular fibrillation

Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault >30%)?

Initial non-operative treatment strategy versus appendectomy treatment strategy for simple appendicitis in children aged 7- 17 years old. APAC study

Economic evaluation of psychiatric rehabilitation/self-management group intervention (PPEP4All) compared with usual care in patients with Persistent Depressive Disorder (PDD) and their partner; a multicenter pragmatic randomized controlled trial

Clinical impact of dedicated MR staging of ovarian cancer patients

Supplemental oxygen strategies in children with bronchopulmonary dysplasia (BPD) after the neonatal intensive care period: the SOS BPD study.

Effectiviteit van antibacteriële verbandmiddelen bij constitutioneel eczeem

GERiatric Screening in the treatment of elderly patients with Ovarian Carcinoma (GERSOC)

MR Proper: Risk assessment and MR imaging in prostate cancer diagnosis: an impact analysis

Proclion - Prospective evaluation of interventions for critical limb ischemia

The (cost)effectiveness of neoadjuvant FOLFIRINOX versus upfront surgery for (borderline) resectable pancreatic cancer.

Cost-effectiveness of immediately versus delayed sequential bilateral cataract surgery (ISBCS vs. DSBCS)

Surgical Approach of Hemiarthroplasty after Femoral Neck Fracture: Posterolateral or Direct Lateral (APOLLO)

Effectiveness of Continuous Glucose Monitoring versus stepped Care starting with HypoAware, A Web-Based Psychoeducational Intervention, and adding CGM as needed, in Adult Type 1 Diabetes and Impaired Hypoglycemia Awareness: A Randomized Controlled Trial

Effectiveness of Continuous Glucose Monitoring versus stepped Care starting with HypoAware, A Web-Based Psychoeducational Intervention, and adding CGM as needed, in Adult Type 1 Diabetes and Impaired Hypoglycemia Awareness: A Randomized Controlled Trial

Improvement of quality of life with home dialysis compared to in-centre haemodialysis? The DOMESTICO project

Improvement of quality of life with home dialysis compared to in-centre haemodialysis? The DOMESTICO project

Cost-effectiveness of specialized nursing interventions for patients with Parkinson’s disease

EFFectiveness of total Extraperitoneal hernia Correction for clinically occulT inguinal hernia (EFFECT trial): a multicenter randomized controlled trial

Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in The Netherlands for Late arrivals: MR CLEAN-LATE

Klinische en kosteneffectiviteit van gerichte nazorg voor patiënten met mogelijke cognitieve en emotionele klachten na een TIA of kleine beroerte, die rechtstreeks uit het ziekenhuis naar huis ontslagen kunnen worden

New AntiBiotic treatment Options for uncomplicated GOnorrhoea (NABOGO trial) - a double-blind randomized controlled non-inferiority trial

Lengthening Adalimumab Dosing Interval in quiescent Crohn’s disease patients: the LADI study.

Optimising anticoagulant management in frail elderly patients with AF: the FRAIL-AF study.

Optimising anticoagulant management in frail elderly patients with AF: the FRAIL-AF study

Intravenous-to-oral antibiotic switch therapy for suspected neonatal infections: clinical efficacy, safety and cost-effectiveness.

Non-inferiority multicentre randomized controlled trial comparing a short versus a long course of postoperative antibiotic treatment for complex acute appendicitis

CARRIER-trial: Long-term StaphyloCoccus aureus decolonizAtion in patients on home parenteRal nutRition: a randomIzed multicEnter tRial.

Efficacy and cost analysis of oral alitretinoin versus oral cyclosporine in patients with severe chronic vesicular hand eczema. A randomized controlled prospective open-label trial with blinded outcome assessment.

Optimizing osteoporosis treatment outcomes: shared-decision making and adherence support program

Pharmacogenetics to improve personalized antidepressant dosing in patients with severe depression;a randomized controlled trial using Tricyclic Antidepressants

Tailored treatment of functional dyspepsia with nortriptyline: a multi-center double-blind placebo-controlled trial (TENDER)

Chronotherapy with aspirin for reduction of cardiovascular disease (TImE ASPIRIN)

Chronotherapy with aspirin for reduction of cardiovascular disease (TImE ASPIRIN)

Withdrawing off-label antipsychotics in people with intellectual disabilities: why does it fail?

Individualized PeMetRexed dOsing in lung cancER and mesothelioma patients to improVE treatment response and allow treatment of patients with impaired renal function – The IMPROVE study (previous acronym: PROPER study).

Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP (OPTIC trial)

Pharmacokinetic boosting of osimertinib in patients with non-small cell lung cancer using cobicistat

Prudent medication management in the last phase of life

Prudent medication management in the last phase of life

Leiden Thrombosis Risk Prevention: Tailored treatment after a first venous thromboembolism (L-TRiP study)

Leiden Thrombosis Risk Prevention: Tailored treatment after a first venous thromboembolism (L-TRiP study)

Dose lndividualizAtion of Beta-lactam AntiBiotics in ICU patients: to TDM or not to TDM and the effects on patient outcome'

Dose lndividualizAtion of Beta-lactam AntiBiotics in ICU patients: to TDM or not to TDM and the effects on patient outcome

Pregnancy Outcomes: Effects of Metformin (POEM) study: a long term randomized controlled trial

Posaconazole prophylaxis to prevent influenza-associated aspergillosis in critically ill patients: a randomized trial.

DA VINCY trial: optimal Duration of Aprepitant therapy for nausea and Vomiting INduced by ChEmotherapY in children: a double-blind placebo-controlled crossover randomized phase III trial

Autologous hematopoietic stem cell transplantation versus conventional immunosuppressive medication in early diffuse cutaneous systemic sclerosis: an international multicenter, open-label, randomized controlled trial

Autologous hematopoietic stem cell transplantation versus conventional immunosuppressive medication in early diffuse cutaneous systemic sclerosis: an international multicenter, open-label, randomized controlled trial

The effect of proactive versus reactive treatment of hypotension on postoperative disability and outcome in surgical patients under anesthesia (PRETREAT): an adaptive, multicenter randomized controlled trial

Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteremia (SAFE-trial)

Safe shortening of antibiotic treatment duration for complicated Staphylococcus aureus bacteremia (SAFE-trial)

Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the perioperative period: to withdraw or to continue?

Personalized dose reduction of biological drugs in Rheumatoid Arthritis patients using dynamic prediction

Wound Infections Following Implant Removal (WIFI-2)

Reduced Anticoagulation Targets in Extracorporeal life support (RATE)'

Less is more: deprescribing of glucose lowering drugs in older people with Type 2 Diabetes mellitus

OPERA Netherlands study of Optimal, PERsonalized Antidepressant use

OPERA Netherlands study of Optimal, PERsonalized Antidepressant use

Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: a prospective randomised multi-center double-blind placebo-controlled clinical trial

To continue or not to continue... a randomized controlled trial of maintenance treatment versus discontinuation of antipsychotic medication following remission of a first psychosis.

Atosiban versus placebo in the treatment of late threatened preterm labor (APOSTEL VIII study)

OPTIMIZE trail: OPen label multicentre randomized Trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetilwith a low exposure tacrolimus regimen ln combination with everolimus in de novo renal transplantation in Elderly patients'.

The safety and cost-effectiveness of discontinuing disease modifying therapies in stable relapsing-remitting multiple sclerosis (DOT-MS) : a randomized rater-blinded multicenter trial

LT4/LT3 Combination therapy for hypothyroidism (T3-4-Hypo trial)

ACTION-1: ACT guided heparinization during open abdominal aortic aneurysm repair, a randomised trial

DUTCH-AF Registry - Prospective evaluation of dosing and adherence of anticoagulant treatment and the risk for bleeding in atrial fibrillation (NOAC)

SONIA - Endocrine therapy plus CDK 4/6 inhibition in first or second line for hormone receptor positive advanced breast cancer

Control Crohn Safe with episodic adalimumab monotherapy as first line treatment trial (Futurelab)

Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands (DECISION)

Transmural Trauma Care Model

Multicentre randomized clinical trial in resuscitation of preterm infants at birth with intact umbilical cord: The Aeration, Breathing and then Clamping (ABC) Study

Hernia Exploration oR Not In Infants Analysis (HERNIIA-trial): A randomized controlled trial to study the effectiveness and cost-effectiveness of contralateral surgical exploration during unilateral inguinal hernia repair in children.

Improving the quality of life of patients with breast cancer-related lymphedema by lymphaticovenous anastomosis (LVA): A randomized controlled trial.

Evaluating the utility of bone grafts in open wedge corrective osteotomy and plate fixation in patients with malunited distal radius fractures (WOPPeR trial)

Cost-effectiveness of early fixation versus conservative therapy of multiple, simple rib fractures (FixCon); a multicenter Randomized Controlled Trial

The Driving prEsSure durIng GeNeral AnesThesIa for abdOmiNal surgery (DESIGNATION) trial

Face-to-face vs Online Hypnotherapy for the treatment of Irritable Bowel Syndrome (FORTITUDE)

Cost-effectiveness of rTMS/CBT as next step in antidepressant non-responders. A randomized comparison with current stepped care approaches to major depressive disorder

The TRIASSIC study: Multicentre, randomised controlled trial comparing TRansanal minimal InvAsive Surgery (TAMIS) and endoscopic Submucosal dIsseCtion (ESD) for resection of non-pedunculated rectal lesions.

Induction of labour in hospital with a Foley catheter or oral misoprostol versus induction of labour at home with Foley catheter or oral misoprostol (PROBAAT-III): a multicentre randomized controlled trial with cost-effectiveness analysis.

Cost-effectiveness of a transmural integrated care program for knee arthroplasty patients in the working population

Cost-effectiveness of a transmural integrated care program for knee arthroplasty patients in the working population

Surgical or Medical treatment of Endometrioma (SOMA trial)

Acute rule out of non-ST segment elevation acute coronary syndrome in the (pre)hospital setting by HEART score assessment and a single point of care troponin. The ARTICA randomized trial

Acute rule out of non-ST segment elevation acute coronary syndrome in the (pre)hospital setting by HEART score assessment and a single point of care troponin. The ARTICA randomized trial

The THumb osteoarthritis Exercise TriAl (THETA); a multicenter, randomized controlled trial on exercise therapy with an orthosis compared to an orthosis alone in patients with thumb base osteoarthritis

The THumb osteoarthritis Exercise TriAl (THETA); a multicenter, randomized controlled trial on exercise therapy with an orthosis compared to an orthosis alone in patients with thumb base osteoarthritis

Dedicated MR imaging vs surgical staging of peritoneal carcinomatosis in colorectal cancer patients; a randomised multicenter trial.

Paravertebral catheter versus Epidural analgesia in Minimally Invasive Esophageal Resection: a randomized controlled multicenter trial (PEPMEN trial)

How should we treat a patient with a distal radius fracture after closed reduction? A cluster RCT

Cost-effectiveness and effectiveness of rubber band ligation versus sutured mucopexy versus haemorrhoidectomy in patients with recurrent haemorrhoidal disease: a multicentre, randomized controlled trial

Outcome and cost-effectiveness of a dynamic Lucerne-cast versus immobilization by forearm-cast in patients with FraCtures (neck, sHaft, intra-Articular) of the MetacarPAl bone, requirinG Non-operative trEatment. SHORT-TITLE: CHAMPAGNE-study

The value of a decision aid for shared decision making in surgical and orthopedic practice. A multicenter costeffectiviness analysis.

GOLD study: Glioblastoma, Optimizing Logistics and Dose.

CRyoballoon Ablation versus mediCal thErapy in patients with Heart Failure and atrial fibrillation: a multicenter randomized clinical trial, the RACE-8-HF trial

The effects of Automated Closed-loop versus convenTIonal VEntilation on duration and quality of ventilation (‘ACTIVE’) - a randomized clinical trial in intensive care unit patients

Which patient with an anterior cruciate ligament rupture will need a surgical reconstruction?

Which patient with an anterior cruciate ligament rupture will need a surgical reconstruction?

Retaining or removing the joint in the foot? A randomized controlled multicenter trial of primary arthrodesis versus joint stabilisation in Lisfranc fracture dislocation midfoot injuries.

The Cerebro Placental Ratio as indicator for delivery in perception of reduced fetal movements (CEPRA-study).

6-week mortality in patients treated with azole-echinocandin duo-therapy versus azole monotherapy. A randomized pragmatic superiority trial (DUET study)

6-week mortality in patients treated with azole-echinocandin duo-therapy versus azole monotherapy. A randomized pragmatic superiority trial (DUET study)

Dose reduction of the new generation biologics (1L17 and lL23 inhibitors) in psoriasis: A pragmatic, multicentre, randomized, controlled, non-inferiority study - BeNeBio study

Survival and Quality of Life after Early Surgical Intervention versus Wait-and-See in Elderly patients with a Traumatic Acute Subdural Hematoma: a pragmatic randomized controlled trial with multicentre parallel group design (RESET ASDH study).

The impact of high versus standard enteral protein provision on functional recovery following Intensive Care admission: a randomized controlled, multicenter, parallel group trial in mechanically ventilated, critically ill patients

CAPP Behandeling van complexe appendicitis bij kinderen; directe appendectomie of initieel non-operatieve behandeling?

Behandeling van complexe appendicitis bij kinderen; directe appendectomie of initieel non-operatieve behandeling?

DIALOGICA Samen op weg naar betere besluitvorming over wel of geen dialyse bij de oudere patiënt. (DIALOG: DIALysis or not: Outcomes in older kidney patients with Geriatric assessment)

Samen op weg naar betere besluitvorming over wel of geen dialyse bij de oudere patiënt. (DIALOG: DIALysis or not: Outcomes in older kidney patients with Geriatric assessment)

MIRA 2 A randomised controlled trial comparing Endometrial abLation alone versus Endometrial Ablation and levoNORgesterol releasing intrauterine system combined

A randomised controlled trial comparing Endometrial abLation alone versus Endometrial Ablation and levoNORgesterol releasing intrauterine system combined

OASIS De optimale chirurgische strategie voor het creëren van een vaattoegang bij oudere dialysepatiënten

De optimale chirurgische strategie voor het creëren van een vaattoegang bij oudere dialysepatiënten

PINOT Optimale behandelingstrategie voor meest voorkomende handfracturen en -luxaties

Optimale behandelingsstrategie voor meest voorkomende handfracturen en -luxaties

STONE Effectiviteit van nefrostomiecatheter versus double J catheter bij patienten met obstructief niersteenlijden

Effectiviteit van nefrostomiecatheter versus double J catheter bij patiënten met obstructief niersteenlijden

DM - Gerandomiseerd onderzoek naar effecTieve behANdelinG vOlgens nieuwe criteria zwangerschaps Diabetes Mellitus