Does endometrial scratching increase the rate of spontaneous conception in couples with unexplained infertility and a good prognosis (Hunault >30%)?
Initial non-operative treatment strategy versus appendectomy treatment strategy for simple appendicitis in children aged 7- 17 years old. APAC study
The effects of Automated Closed-loop versus convenTIonal VEntilation on duration and quality of ventilation (‘ACTIVE’) - a randomized clinical trial in intensive care unit patients
Which patient with an anterior cruciate ligament rupture will need a surgical reconstruction? Which patient with an anterior cruciate ligament rupture will need a surgical reconstruction?
Retaining or removing the joint in the foot? A randomized controlled multicenter trial of primary arthrodesis versus joint stabilisation in Lisfranc fracture dislocation midfoot injuries.
6-week mortality in patients treated with azole-echinocandin duo-therapy versus azole monotherapy. A randomized pragmatic superiority trial (DUET study) 6-week mortality in patients treated with azole-echinocandin duo-therapy versus azole monotherapy. A randomized pragmatic superiority trial (DUET study)
Dose reduction of the new generation biologics (1L17 and lL23 inhibitors) in psoriasis: A pragmatic, multicentre, randomized, controlled, non-inferiority study - BeNeBio study
Survival and Quality of Life after Early Surgical Intervention versus Wait-and-See in Elderly patients with a Traumatic Acute Subdural Hematoma: a pragmatic randomized controlled trial with multicentre parallel group design (RESET ASDH study).
The impact of high versus standard enteral protein provision on functional recovery following Intensive Care admission: a randomized controlled, multicenter, parallel group trial in mechanically ventilated, critically ill patients
OPERA Netherlands study of Optimal, PERsonalized Antidepressant use OPERA Netherlands study of Optimal, PERsonalized Antidepressant use
Efficacy of haloperidol to decrease the burden of delirium in adult critically ill patients: a prospective randomised multi-center double-blind placebo-controlled clinical trial
To continue or not to continue... a randomized controlled trial of maintenance treatment versus discontinuation of antipsychotic medication following remission of a first psychosis.
OPTIMIZE trail: OPen label multicentre randomized Trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetilwith a low exposure tacrolimus regimen ln combination with everolimus in de novo renal transplantation in Elderly patient
The safety and cost-effectiveness of discontinuing disease modifying therapies in stable relapsing-remitting multiple sclerosis (DOT-MS) : a randomized rater-blinded multicenter trial
DUTCH-AF Registry - Prospective evaluation of dosing and adherence of anticoagulant treatment and the risk for bleeding in atrial fibrillation (NOAC)
SONIA - Endocrine therapy plus CDK 4/6 inhibition in first or second line for hormone receptor positive advanced breast cancer
Digoxin Evaluation in Chronic heart failure: Investigational Study In Outpatients in the Netherlands (DECISION)
Multicentre randomized clinical trial in resuscitation of preterm infants at birth with intact umbilical cord: The Aeration, Breathing and then Clamping (ABC) Study
Hernia Exploration oR Not In Infants Analysis (HERNIIA-trial): A randomized controlled trial to study the effectiveness and cost-effectiveness of contralateral surgical exploration during unilateral inguinal hernia repair in children.
Improving the quality of life of patients with breast cancer-related lymphedema by lymphaticovenous anastomosis (LVA): A randomized controlled trial.
